Inhibitors of the formation of soluble human CD23

摘要

A pharmaceutical composition for the treatment or prophylaxis of disorders is described in which the overproduction of s-CD23 is implicated. This composition comprises an inhibitor for the formation of human soluble CD23 which inhibitor decreases or blocks selectively the activity of the metalloprotease ADAM9 which otherwise mediates the shedding of s-CD23 in human B cell lines. Also described is a pharmaceutical composition wherein the inhibitor for the formation of human soluble CD23 is a monoclonal or polyclonal antibody directed against the metalloprotease ADAM9 or wherein the inhibitor is an antisense oligonucleotide which is specific for c-myc. Such a pharmaceutical composition may be used in a method for selectively inhibiting the formation of ADAM9 as well as the formation of s-CD23. It is a suitable medicament against inflammatory disorders, autoimmune diseases and allergy.