COMPOUNDS ACTIVE AT THE GLUCOCORTICOID RECEPTOR III

摘要

This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in therapy and in the regulation of metabolism, especially lowering blood glucose levels. The compounds referred to are compounds according to the formula (I): wherein R<1> is selected from: COOH and heteroaryl; R<2> and R<3> are independently of each other selected from: hydrogen, halogen, and C1-6-alkyl, provided that one of R<2> or R<3> other than hydrogen; R<4> is selected form: C1-6-alkyl, C3-8-alkenyl, and C2-6-alkynyl; R<5> is selected form: hydrogen, C1-12-alkyl, C2-6-alkenyl and C2-6-alkynyl; R<6> and R<7> are independently of each other selected from: aryl, heteroaryl, and C3-8-heterocycloalkyl; or pharmaceutically acceptable salts, stereoisomers or prodrugs thereof.