SUBSTITUTED CARBOXYLIC ACID DERIVATIVES

摘要

Novel substituted carboxylic acid derivatives which bind to human peroxisome proliferator-activated receptor alpha (PPAR alpha ) as a ligand thereof and activate the same, thereby being efficacious as remedies for metabolic diseases such as lipid-lowering drugs (particularly in the liver), drugs preventing the progress of arteriosclerosis, anti-obesity drugs and remedies for diabetes; and a process for producing the same. Namely, substituted carboxylic acid derivatives represented by the following general formula (1), esters thereof and pharmaceutically acceptable salts and hydrates of the same; and a process for producing these compounds: (1) wherein R<1> represents hydrogen, halogeno, hydroxy, 2-phenylethyl, 2-phenylethoxy, hydroxyphenoxy or benzyloxyphenoxy; and R<2> represents lower (C1-4) alkyl.