发明名称 |
METHOD FOR PRODUCING AN IMMUNOTROPIC ANTIVIRAL PREPARATION |
摘要 |
The invention relates to the chemical pharmaceutical industry, in particular to a method for producing an immunotropic preparation exhibiting a high antiviral activity with respect to RNA and DNA viruses. In order to produce the inventive preparation, fat-free sturgeon or salmon milt, or a calf thymus, or chicken blood, or porcine liver is pulverised and homogenised in a saline citrate solution. The produced homogenate is incubated in the presence of a detergent, a calcium chlorine solution being added at a high temperature. Afterwards, said homogenate is treated by ultrasound, a sorbent and detergent and concentrated, thereby producing a white amorphous deposit of DNA which has the following characteristics: a molecular mass ranging from 270 to 500 kD, a hyperchromatic action not less than 37 %, a protein content of less than 1 %. The DNA deposit is dried and the obtained powder is diluted in an aqueous solution of the following transition metal: Zn, Co, Mn, Sb, whereby a 1.5 % sterilised solution having a hyperchromatic action equal to or higher than 10 % is obtained.
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申请公布号 |
WO0243740(A1) |
申请公布日期 |
2002.06.06 |
申请号 |
WO2001RU00171 |
申请日期 |
2001.04.24 |
申请人 |
KAPLINA, ELLI NIKOLAEVNA;LADYGINA, ALEXANDRA YUREVNA;KAPLIN, VALERY YUREVICH;VAINBERG, MIHAIL YUREVICH |
发明人 |
KAPLINA, ELLI NIKOLAEVNA;LADYGINA, ALEXANDRA YUREVNA;KAPLIN, VALERY YUREVICH;VAINBERG, MIHAIL YUREVICH |
分类号 |
A61K31/70;A61K31/711;A61K33/24;A61K33/30;A61K33/32;A61K35/14;A61K35/26;A61K35/407;A61K35/60;A61P31/14;(IPC1-7):A61K31/70;C07H21/04;A61K35/28;A61K35/55 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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