发明名称 |
GENERATION OF COMBINATORIAL LIBRARIES AND ASSESSMENT THEREOF BY DECONVOLUTION |
摘要 |
The present invention deals with a method for the generation of a dynamic combinatorial library of ligands for a given target, capable of binding at least two functionalities, which method comprises the following steps: (i) selecting a set of n molecules carrying functionalities which may bind to the target, which molecules are capable of reversibly binding to each other under formation of an entity, n being an integer ≥ 1; (ii) mixing together said set of said n molecules; (iii) subjecting the mixture to conditions allowing a reversible bond formation and cleavage under formation of entities carrying different combinations of functionalities, until equilibrium is reached; (iv) optionally transforming the said entities into ligands; (v) repeating steps (i) to (iv) n-times, each time a different molecule of said set of n molecules being omitted; (vi) assessing the ability of each of the mixtures obtained to bind to a given target. |
申请公布号 |
WO0220435(A3) |
申请公布日期 |
2002.06.06 |
申请号 |
WO2001EP10170 |
申请日期 |
2001.09.04 |
申请人 |
THERASCOPE AG;LEHN, JEAN-MARIE;RAMSTROEM, OLOF;BUNYAPAIBOONSRI, TARIDOPORN |
发明人 |
LEHN, JEAN-MARIE;RAMSTROEM, OLOF;BUNYAPAIBOONSRI, TARIDOPORN |
分类号 |
G01N33/15;A61K45/00;C07B61/00;C07C211/63;C07C243/34;C12Q1/44;C12Q1/527;C40B20/06;C40B40/02;C40B50/06 |
主分类号 |
G01N33/15 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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