发明名称 |
DNA vaccination for treatment of autoimmune disease |
摘要 |
A pro-inflammatory T cell response is specifically suppressed by the injection into a recipient of DNA encoding an autoantigen associated with autoimmune disease. The recipient may be further treating by co-vaccination with a DNA encoding a Th2 cytokine, particularly encoding IL4. In response to the vaccination, the proliferation of autoantigen-reactive T cells and the secretion of Th1 cytokines, including IL-2, IFN-gamma and IL-15, are reduced.
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申请公布号 |
US2002068715(A1) |
申请公布日期 |
2002.06.06 |
申请号 |
US20010947770 |
申请日期 |
2001.09.05 |
申请人 |
STEINMAN LAWRENCE;RUIZ PEDRO;GARREN HIDEKI |
发明人 |
STEINMAN LAWRENCE;RUIZ PEDRO;GARREN HIDEKI |
分类号 |
A01K67/027;A61K39/00;A61K39/39;A61K48/00;C07K14/62;(IPC1-7):A61K48/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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