| 摘要 |
<p>The invention concerns a method for detecting a compound modulating complexing between RNA polymerase and a protein intervening during transcription, which consists in: incubating a mixture comprising RNA polymerase intervening during transcription and the compound to be detected; detecting, by a complexing test, the possible significant variation of the amount of complex formed between RNA polymerase and said protein relative to a control value corresponding to the amount of complex formed between RNA polymerase and said protein in the absence of any modulator; and deducing therefrom, when there is a significant variation as defined above, that there has been formation of a bond between said compound and RNA polymerase and/or the protein intervening during transcription, which results in a modulation of the complexing between RNA polymerase and the protein intervening during transcription.</p> |
