摘要 |
<p>Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.</p> |
申请人 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;THOMAS JEFFERSON UNIVERSITY;SYNERGY PHARMACEUTICALS, INC. |
发明人 |
ZITZMANN, NICOLE;BUTTERS, TERRY, D.;PLATT, FRANCES M.;CARROUEE, SANDRA;JACOB, GARY, S;PICKER, DONALD H.;FLEET, GEORGE ,W.J;DWEK, RAYMOND, A;DURANTEL, DAVID;MEHTA, ANAND;BLOCK, TIMOTHY, M |