ORAL DRUG DELIVERY SYSTEM FOR ENHANCING THE BIOAVAILABILITY OF ACTIVATED GLYCYRRHETIN

摘要

A drug delivery system for enhancing the bioavailability of glycyrrhizin is disclosed. The system is a colon-targeted, oral drug delivery system containing a sufficient amount of glycyrrhizin to overwhelm the rate of hydrolysis thereof by the intestinal flora in admixture with a pharmaceutically acceptable carrier. Preferably all or a part of the carrier consists of an adsorption promoter selected from the group consisting of a pharmaceutically acceptable organic acid, a surfactant and a chelating agent.