Nye hydronaftalenforbindelsen fremstilt ved rhodiumkatalysert ringåpningsreaksjon i n¶rv¶r av fosfinligand

摘要

The present invention is directed to a procedure for making an enantiomerically enriched compound containing a hydronaphthalene ring structure. The process involves reacting oxabenzonorbornadienes with nucleophiles using rhodium as a catalyst and in the presence of a phosphine ligand. The compounds synthesized may be used in pharmaceutical preparations for the treatment of a variety of diseases and conditions.