发明名称 |
HEPATOBILIARY MAGNETIC RESONANCE CONTRAST AGENTS |
摘要 |
<p>A compound of the formula: <CHEM> wherein R<1> and R<2> are both hydrogen and R<3> and R<4> together with the carbon atoms in the tetraazacyclododecane macrocycle to which they are attached form a fused fully or partially saturated non aromatic cyclohexyl ring which may be unsubstituted or substituted by one or more halogen, straight or branched (C1-C5)alkyl, alkyl oxide of formula -R-OR wherein each R is a straight or branched (C1-C5)alkyl, hydroxy or hydroxyalkyl groups, and which may be further fused to a phenyl or cyclohexyl ring <CHEM> p is 0 or 1 and R6 is hydrogen or a straight or branched (C1-C5) alkyl group; or a salt thereof and the metal chelates thereof, particularly gadolinium chelates, the pharmaceutical and diagnostic compositions containing them and their use in MRI.</p> |
申请公布号 |
EP0670832(B1) |
申请公布日期 |
2002.06.05 |
申请号 |
EP19940926365 |
申请日期 |
1994.09.29 |
申请人 |
BRACCO INTERNATIONAL B.V. |
发明人 |
DESREUX, JEAN-FRANCOIS;TWEEDLE, MICHAEL, F.;RATSEP, PETER, C.;WAGLER, THOMAS, R.;MARINELLI, EDMUND, R. |
分类号 |
A61K49/00;C07D257/02;C07D257/10;C07F5/00;(IPC1-7):C07D257/10 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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