发明名称 |
Process for producing N-acetyl-neuraminic acid |
摘要 |
The present invention provides a process for economically producing N-acetylneuraminic acid without using expensive materials such as pyruvic acid and phosphoenolpyruvic acid. The process comprises: allowing (i) a culture of a microorganism having N-acetylneuraminic acid aldolase activity or N-acetylneuraminic acid synthetase activity, or a treated matter of the culture, (ii) a culture of a microorganism capable of producing pyruvic acid or a treated matter of the culture, or a culture of a microorganism capable of producing phosphoenolpyruvic acid or a treated matter of the culture, (iii) N-acetylmannosamine, and (iv) an energy source which is necessary for the formation of pyruvic acid or phosphoenolpyruvic acid to be present in an aqueous medium to form and accumulate N-acetylneuraminic acid in the aqueous medium; and recovering N-acetylneuraminic acid from the aqueous medium. |
申请公布号 |
EP1081230(A3) |
申请公布日期 |
2002.06.05 |
申请号 |
EP20000118139 |
申请日期 |
2000.08.29 |
申请人 |
KYOWA HAKKO KOGYO CO., LTD. |
发明人 |
KOIZUMI, SATOSHI;TABATA, KAZUHIKO;ENDO, TETSUO;OZAKI, AKIO |
分类号 |
C12N15/09;C12N1/19;C12N1/21;C12N9/00;C12N9/88;C12P19/26;C12R1/15;C12R1/19;C12R1/85 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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