发明名称 |
Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from uncaria tomentosa and related plants |
摘要 |
Assay-guided affinity fractionation and reverse phase high pressure liquid chromatography (HPLC) methodology to isolate, test and characterize the most active water-soluble ingredients within Cat's Claw, or Uncaria tomentos. These components appear to account for the majority of the amyloid or Abeta fibrillogenesis inhibitory activity. Individual fractions and/or compounds as isolated by HPLC are tested in relevant in vitro and/or animal models, and found to consistently demonstrate inhibition of amyloid or Abeta fibrillogenesis. Related extraction methods are disclosed. |
申请公布号 |
AU3976402(A) |
申请公布日期 |
2002.06.03 |
申请号 |
AU20020039764 |
申请日期 |
2001.11.02 |
申请人 |
PROTEOTECH, INC. |
发明人 |
GERARDO CASTILLO;PAULA Y. CHOI;BETH NGUYEN;ALAN D. SNOW |
分类号 |
A61K31/353;A61K31/215;A61K31/216;A61K31/35;A61K36/00;A61K36/18;A61K36/74;A61P3/10;A61P25/00;A61P25/28;A61P31/00;A61P35/00;A61P43/00;C12N;C12N9/99 |
主分类号 |
A61K31/353 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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