| 摘要 |
A metal-chelating ligand-support conjugate comprises coordination groups selected from COOH, PO3H and SO3H bound to a ligand backbone, the ligand backbone is linked, optionally by means of a spacer, to a support matrix, and the ligand backbone/spacer is free of ester and amide bonds. Such a conjugate may be prepared by the reaction of a polyamine of the formula H-[NH-A]n-NH2 with an activated support matrix Z-Y, wherein Y is a reactive group, optionally in the presence of or after reaction of either component with a compound introducing M; and reaction of the product with a compound of the formula Q-CH2-X, wherein Q is a group reactive with NH. |
