| 摘要 |
A method for the treatment of a patient having, or susceptible to having, symptoms of a disorder or dysfunction comprises administering a non-fibrous linear poly(ethylenimine) diazeniumdiolate to the patient wherein said linear poly(ethylenimine) diazeniumdiolate is capable of releasing a therapeutically effective amount of nitric oxide sufficient to alleviate the symptoms of the disorder or dysfunction. A method for delivering nitric oxide to the lungs comprises the steps of synthesizing a non-fibrous linear poly(ethylenimine) diazeniumdiolate, wherein the non-fibrous linear poly(ethylenimine) diazeniumdiolate has a ratio of N2O2- substituted amines to unsubstituted amines greater than 1.0; and administering said non-fibrous linear poly(ethylenimine) diazeniumdiolate to the lungs. A method for lowering the pulmonary blood pressure of a patient having lungs, without significantly affecting the systemic vascular blood pressure of the patient comprises the steps of synthesizing a non-fibrous linear poly(ethylenimine) diazeniumdiolate, wherein the non-fibrous linear poly(ethylenimine) diazeniumdiolate has a ratio of N2O2- substituted amines to unsubstituted amines greater than 1.0; and administering said non-fibrous linear poly(ethylenimine) diazeniumdiolate to the lungs. |
