The invention concerns a method which can be used to screen two or more repertoires of molecules against one another and/or to create combinatorial repertoires by combining two or more repertoires. In particular, the invention relates to a method whereby two repertoires of molecules can be screened such that substantially all members of the first repertoire are tested against substantially all members of the second repertoire for functional interactions. Furthermore, the invention relates to the creation and screening of antibody repertoires by combining a repertoire of heavy chains with a repertoire of light chains such that antibodies formed by the substantially all combinations of heavy and light chains can be screened against one or more target ligands.
申请公布号
WO0198534(A3)
申请公布日期
2002.05.30
申请号
WO2001GB02831
申请日期
2001.06.22
申请人
DIVERSYS LIMITED;HOLT, LUCY, JESSICA;TOMLINSON, IAN