PROCESS FOR THE PREPARATION OF A beta -LACTAM NUCLEUS AND THE APPLICATION THEREOF

摘要

The invention relates to a process for the preparation of an aqueous solution or suspension of a beta -lactam nucleus and application thereof. The aqueous solution or suspension of the beta -lactam nucleus is prepared by process wherein an enzymatic deacylation of a beta -lactam compound, which compounds comprises a beta -lactam nucleus with a side chain coupled to it via an amide bond and which deacylation reaction is carried out in a mixture of water and an organic solvent and which deacylation leads to a beta -lactam nucleus and a carboxylic acid, is carried out at a pH value of between 2 and 6 so that the carboxylic acid is extracted in situ to the organic solvent.