发明名称 |
HOMOLOGOUS 28-KILODALTON IMMUNODOMINANT PROTEIN GENES OF EHRLICHIA CANIS AND USES THEREOF |
摘要 |
The present invention is directed to the cloning, sequencing and expression of homologous immunoreactive 28-kDa protein genes, p28-1, -2, -3, -5, -6, -7, -9, from a polymorphic multiple gene family of <i>Ehrlichia canis</i>. Further disclosed is a multigene locus encoding all nine homologous 28-kDa protein genes of <i>Ehrlichia canis</i>. Recombinant <i>Ehrlichia canis</i> 28-kDa proteins react with convalescent phase antiserum from an <i>E.canis</i>-infected dog, and may be useful in the development of vaccines and serodiagnostics that are particularly effective for disease prevention and serodiagnosis. |
申请公布号 |
WO0222782(A3) |
申请公布日期 |
2002.05.30 |
申请号 |
WO2001US28759 |
申请日期 |
2001.09.12 |
申请人 |
RESEARCH DEVELOPMENT FOUNDATION |
发明人 |
WALKER, DAVID, H.;YU, XUE-JIE;MCBRIDE, JERE, W. |
分类号 |
C12N15/09;A61K38/00;A61K39/00;A61P31/00;C07K14/195;C07K14/29;C07K16/12;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/117;C12P21/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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