| 摘要 |
A truncated form of the full-length, immunosuppression-inducing molecule, CD200, CD200tr, was expressed in CHO cells and the transduced cells used to produce mAbs to CD200tr. These mAbs detect simultaneous expression of full-length CD200 and CD200tr in LPS-stimulated dendritic cells (DCs). Moreover, CHO cells and DCs expressing CD200tr as well as soluble CD200tr are able to inhibit suppression of mixed leucocyte reactions <i>in vitro</i> which follows addition of the soluble form of CD200 (CD200:Fc) in culture, demonstrating that CD200tr is a physiological antagonist of CD200. |
