发明名称 |
Sustained release and long residing ophthalmic formulation and the process of preparing the same |
摘要 |
The present invent relates to sustained release and long residing ophthalmic formulation having thermosensitivity, mucoadhesiveness, hydro gel properties and small particle size. The said formulation comprises of micelle solution of random block co-polymer having a hydrophobic component and a hydrophilic component of general formula -(X+Y+Z-)m, wherein m is an integer greater than 2 X is a monomer which will provide hydrogel formation properties of the co-polymer to reduce the irritability of the eye and is selected from vinyl group of compounds Y is a monomer which will provide thermosensitivity properties of the co-polymer having a general formula R1-R2N-(C=O)-CH=CH2, R1=a proton or CnH2n+1 in which n may have the value from 3 to 6 and R2=alkyl group having chain length of C3 to C6 Z is a monomer which will provide mucoadhesiveness and pH-sensitivity properties to the co-polymer and is selected from acrylate based monomers at least one hydrophobic drug with the said block co-polymer solution; The invention also provides a process of preparing said formulation.
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申请公布号 |
US2002064513(A1) |
申请公布日期 |
2002.05.30 |
申请号 |
US20010954722 |
申请日期 |
2001.09.18 |
申请人 |
MAITRA AMARNATH;GUPTA AJAY KUMAR;MAJUMDAR DIPAK;MADAN SUMIT |
发明人 |
MAITRA AMARNATH;GUPTA AJAY KUMAR;MAJUMDAR DIPAK;MADAN SUMIT |
分类号 |
A61K9/00;A61K9/107;A61K9/51;A61K31/18;A61K31/405;A61K31/407;A61K31/63;A61K47/34;(IPC1-7):A61K31/795;A61K31/785 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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