METHODS FOR REGULATING A CELL-MEDIATED IMMUNE RESPONSE BY BLOCKING LYMPHOCYTIC SIGNALS AND BY BLOCKING LFA-1 MEDIATED ADHESION
摘要
The invention provides methods for regulating cell-mediated immune responses, immune system diseases and allograft transplant rejection by interfering with the interaction of at least three different cell surface molecules with their natural ligands. A first cellular interaction is mediated by CD28/B7/CTLA4, a second interaction is mediated by CD40/CD154, and a third interaction is mediated by LFA-1 interaction with its ligands. Regulation of a cell-mediated immune response affects immune system diseases such as those associated with allograft transplantation.
申请公布号
WO0195928(A3)
申请公布日期
2002.05.30
申请号
WO2001US18619
申请日期
2001.06.08
申请人
BRISTOL-MYERS SQUIBB COMPANY;TOWNSEND, ROBERT, M.;TODDERUD, CHARLES, GORDON;PEACH, ROBERT, J.
发明人
TOWNSEND, ROBERT, M.;TODDERUD, CHARLES, GORDON;PEACH, ROBERT, J.