发明名称 |
Method of controlling the binding of calmyrin to presenilin |
摘要 |
The present invention describes a calcium-binding myristoylated protein with homology to calcineurin B which interacts preferentially with presenilin 2 protein. Also, the present invention relates to methods that alter protein-protein interaction of the calcium-binding myristoylated protein with presenilin 2 thereby reducing deleterious effects of the protein-protein interaction, such as apoptosis. The present invention further relates to introducing and expressing a mutant presenilin 2 protein or mutant calcium-binding myristoylated protein to modulate cell functions relating to calcium signaling and apoptosis.
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申请公布号 |
US2002064828(A1) |
申请公布日期 |
2002.05.30 |
申请号 |
US20010878454 |
申请日期 |
2001.06.11 |
申请人 |
MONTEIRO MERVYN J.;STABLER STACY |
发明人 |
MONTEIRO MERVYN J.;STABLER STACY |
分类号 |
A61K38/00;C07K14/47;C12N5/02;(IPC1-7):A61K38/17;C07K14/435;C12P21/02;C12N5/04;C12N5/06;C07H21/04 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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