| 发明名称 |
Cancer diagnosis and therapy based on mutations in TGF-beta receptors |
| 摘要 |
This invention is based on the discovery that the type II TGFbeta receptor (RII) is a cancer suppressor gene which is genetically inactivated (mutated) in approximately 25% of colon cancers, including nearly all colon cancers of the class identified as mutator/microsatellite instability/RER. Methods are provided for detecting inactivation of RII for use in cancer diagnosis or prognosis.
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| 申请公布号 |
US2002064786(A1) |
申请公布日期 |
2002.05.30 |
| 申请号 |
US20010878905 |
申请日期 |
2001.06.13 |
| 申请人 |
MARKOWITZ SANFORD D.;BRATTAIN MICHAEL G.;WILLSON JAMES K. V. |
发明人 |
MARKOWITZ SANFORD D.;BRATTAIN MICHAEL G.;WILLSON JAMES K. V. |
| 分类号 |
G01N33/50;A61K35/74;A61K38/00;A61K39/00;A61K39/395;A61K48/00;A61P35/00;C07K14/71;C07K16/30;C12N1/21;C12N15/09;C12N15/12;C12P21/02;C12Q1/68;G01N33/574;(IPC1-7):C12Q1/68;G06F19/00;G01N33/48 |
主分类号 |
G01N33/50 |
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