Epothilone resistant cells lines are disclosed. The invention also discloses methods for identifying substances which are cytotoxic to epothilone resistant cells or which are chemosensitizers or analogs of epothilone. The invention further discloses methods for identifying epothiolone resistant cells and for inhibiting the growth of epothilone resistant cells in vitro and in vivo. The invetion also discloses antibodies specific for epothilone resistant cells. Also disclosed is a method to identify microtubule stabilizing agents using the epothilone resistant cell lines disclosed.
申请公布号
WO0242432(A2)
申请公布日期
2002.05.30
申请号
WO2001EP13442
申请日期
2001.11.20
申请人
NOVARTIS AG;NOVARTIS-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H;ATADJA, PETER, WISDOM;WARTMANN, MARKUS;YAN-NEALE, YAN;COHEN, DALIA
发明人
ATADJA, PETER, WISDOM;WARTMANN, MARKUS;YAN-NEALE, YAN;COHEN, DALIA