发明名称 |
TRANSCOBALAMIN RECEPTOR BINDING CONJUGATES FOR NEUTRON CAPTURE THERAPY |
摘要 |
The present invention is directed to neutron capture agents, such as a molecule comprising Boron-10 or Gadolinium-157, for the treatment, prophylaxis and/or diagnosis of a proliferative disorder via a direct or indirect attachment to a compound that binds to a transport protein for vitamin B12, i.e. transcobalamin I, II or III, or intrinsic factor, (the TC- or IF-binding carrier). Subsequent initiation of neutron capture therapy will selectively destroy abnormally proliferating cells. |
申请公布号 |
WO0242318(A2) |
申请公布日期 |
2002.05.30 |
申请号 |
WO2001US50782 |
申请日期 |
2001.10.25 |
申请人 |
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH;REGENTS OF THE UNIVERSITY OF MINNESOTA;COLLINS, DOUGLAS, A.;HOGENKAMP, HENRICUS, P.C. |
发明人 |
COLLINS, DOUGLAS, A.;HOGENKAMP, HENRICUS, P.C. |
分类号 |
A61P35/00;C07H23/00 |
主分类号 |
A61P35/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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