| 摘要 |
Compound of formula (I): wherein X represents a heterocycle bonded to the remainder of the molecule by a nitrogen atom of said heterocycle, or an -NR2R3 group wherein R2 represents hydrogen or alkyl, and R3 represents aryl, 1,3 dihydro-2H-benzimidazolyl-2-one, or alkyl substituted by a heterocycle, n represents zero or 1, R1 represents hydrogen or alkyl, Ra represents a single bond or an alkylene chain, A represents nitrogen or CH, E represents nitrogen or CRe, wherein Re is as defined in the description, Rb represents a single bond or an alkylene chain as defined in the description, W represents aryl or heteroaryl, its optical isomers, and addition salts thereof with a pharmaceutically acceptable acid. Medicinal products containing the same which are useful for treatment of diseases or pathological conditions in which endothelial dysfunction is known.
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