| 摘要 |
Described are neuroprotective agents of Formula I wherein R is an amino acid, a derivative thereof, or nitrogen heterocyclic ring which is saturated or unsaturated of from 5 to 8 members which may have additional oxygen or sulfur atoms therein and which may be substituted by one or more substituents selected from: alkyl of from 1 to 4 carbon atoms, hydroxyl, alkoxy of from 1 to 4 carbon atoms, -CF3, -CN, -amino, -C(O)R11,or -(CH2)n-aryl of from 6 to 12 carbon atoms; R must be attached through a carbon to the quinoxalinyl ring; R1 is H, alkyl of from 1 to 4 carbon atoms, phosphonoalkyl of from 1 to 4 carbon atoms, phosphoroalkyl of from 1 to 4 carbon atoms, carboxyalkyl of from 1 to 4 carbon atoms, -(CH2)mC(O)R11, or hydroxy; R2 is hydrogen, hydroxy, or amine; R3 and R4 are each independently H, alkyl of from 1 to 4 carbon atoms, cycloalkyl of from 5 to 7 carbon atoms, alkenyl of from 2 to 6 carbon atoms, halogen, haloalkyl of from 1 to 6 carbon atoms, nitro, cyano, SO2CF3, CH2SO2R7, (CH2)mCO2R7, (CH2)mCONR7R8, (CH2)mSO2NR8R9, or NHCOR7; R5 is H, alkyl of from 1 to 4 carbon atoms, alkenyl of from 2 to 6 carbon atoms, cycloalkyl of from 5 to 7 carbon atoms, halogen, haloalkyl of from 1 to 4 carbon atoms, -(CH2)maryl of from 6 to 10 carbon atoms, nitro, cyano, SO2CF3, (CH2)mCO2R9, (CH2)mCONR9R10, SO2NR9R10, SO2R7, (CH2)mSO2R7, NHCOR9, -(CH2)mheterocyclic of from 6 to 10 atoms which may contain nitrogen, oxygen, sulfur, and/or -(CH2)<highlight><
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