| 摘要 |
<p>Crystallization apparatus (20) and methods which allow for fast screening and determination of protein crystallization conditions with small protein quantities and rapid crystallization. The apparatus comprise a first region comprising a first nucleation catalyst material (36) and a second region comprising a second nucleation catalyst material (38), with the first and second regions positioned adjacent to each other and configured to support at least one crystal, and with the first region having a variation in a nucleation property of the first nucleation catalyst material (36), in the first region. The crystal may be supported at an interface of the adjacent regions. The methods comprise providing a first region of a first nucleation catalyst material (36) and a second region of a second nucleation catalyst material (38) adjacent said first region, with the first region having a variation in a nucleation property of the first nucleation catalyst material (36), exposing the first and second regions to a solution of a selected molecule, and growing at least one crystal of the molecule in association with the first and second regions.</p> |
