(HYDROXYETHYL)UREAS AS INHIBITORS OF ALZHEIMER'S BETA-AMYLOID PRODUCTION

摘要

Novel (hydroxyethyl)ureas are described. These compounds are effective inhibitors of certain aspartyl proteases, notably secretases involved in the enzymatic cleavage of amyloid precursor protein (APP) to yield amyloid- beta peptide. Methods are provided for administering the novel compunds to treat beta -amyloid-associated diseases, notably Alzheimer's disease.