| 摘要 |
<p>The invention concerns benzimidazole derivatives of general formula (I), wherein: X represents a nitrogen atom or a carbon atom; when X represents a nitrogen atom, R3 represents in particular a hydrogen atom or a C1-C4 alkyl group; R4 represents in particular a hydrogen atom, a C1-C6 alkyl, C3-C7 cycloalkyl, 4-piperidyl, -(CH2)p-NR5R6, -(CH2)p-CONR5R6, -CO-(CH2)p-NR5R6, -(CH2)p-phenyl, -(CH2)p-morpholinyl, -(CH2)p-pyrrolidinyl, -(CH2)p-tetrahydro-isoquinoline, -(CH2)p-heteoraryl, heteroarylcarbonyl, phenylcarbonyl, C1-C6 alkylcarbonyl, -(-CH2)p-COOR', or phenylsulphonyl group; and when X represents a carbon atom, R3 represents a hydrogen atom, a -NR5R6, -NHCOR7, -CONHR5, -COR7, -NHCONH2, -OH or -CH2OH; R4 represents in particular a hydrogen atom, a -(CH2)p-phenyl group optionally substituted, a -(CH2)p-heteroaryl or a (CH2)tNR7R8 group. The compounds of formula (I) of the invention can be used for preparing a medicine for treating or preventing disorders wherein the PARP enzyme is involved.</p> |
