FAT REGULATED GENES, USES THEREOF, AND COMPOUNDS FOR MODULATING SAME

摘要

The present invention relates to methods for identifying genes regulated by fat and their subsequent use in determining compositions for use in the treatment of disease, by utilizing the identified genes and their proteins. The identified compositions regulate the expression of the fat regulated genes or modulate the activity of their protein products. The nucleotide and amino acid sequences for METP, a novel mitochondrial carrier protein and FTF1, a fat responsive transcription factor, are taught. The nucleotide sequence for A1BG, a plasma glycoprotein is taught. The nucleotide and amino acid sequences for human GPAT and rat GLOL are taught. Control sequences for human METP, GLOL, FTF1, SCD, GPAT and A1BG are taught. Polyunsaturated fatty acid regulation functions are taught for SCD1, SCD2, SCD, G6PD, GPAT, FAS, COMT, Apo A-1, INSIG1, FTF1, GLOL, A1GB, Spot-14, delta-3, delta-2-enoyl-CoA isomerase, and METP.