发明名称 |
<i>IN VIVO</i> ANIMAL MODEL OF HUMAN LEUKEMIA |
摘要 |
The present invention provides a process for making an <i>in vivo</i> model of human leukemia. The process includes the steps of: pre-conditioning an immunodeficient rodent by administering to the rodent a sub-lethal dose of irradiation and injecting the rodent with an effective pre-conditioning amount of human fetal cord blood mononuclear cells; maintaining the rodent for from about 5 to 10 days; and injecting the rodent with an effective engrafting amount of primary human leukemia cells. An <i>in vivo</i> and <i>in vitro</i> model of human leukemia are also provided.
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申请公布号 |
WO0216559(A8) |
申请公布日期 |
2002.05.23 |
申请号 |
WO2001EP09661 |
申请日期 |
2001.08.21 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE;NOVARTIS AG;NOVARTIS-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. |
发明人 |
YU, JOHN |
分类号 |
A01K67/027;A61P35/00;C12N5/06;C12N5/10;(IPC1-7):C12N5/06 |
主分类号 |
A01K67/027 |
代理机构 |
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地址 |
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