发明名称 |
COLD-ADAPTED EQUINE INFLUENZA VIRUSES |
摘要 |
<p>The present invention provides experimentally-generated cold-adapted equine influenza viruses, and reassortant influenza A viruses comprising at least one genome segment of such an equine influenza virus, wherein the equine influenza virus genome segment confers at least one identifying phenotype of the cold-adapted equine influenza virus, such as cold-adaptation, temperature sensitivity, dominant interference, or attenuation. Such viruses are formulated into therapeutic compositions to protect animals from diseases caused by influenza A viruses, and in particular, to protect horses from disease caused by equine influenza virus. The present invention also includes methods to protect animals from diseases caused by influenza A virus or other infectious agents utilizing the claimed therapeutic compositions. Such methods include using a therapeutic composition as a vaccine to generate a protective immune response in an animal prior to exposure to an infectious agent, as well as using a therapeutic composition as a treatment for an animal that has been recently infected with an infectious agent leading to respiratory disease, or is likely to be subsequently exposed to such an agent in a few days whereby the therapeutic composition reduces such respiratory disease, even in the absence of antibody-mediated immunity. The present invention also provides methods to produce cold-adapted equine influenza viruses, and reassortant influenza A viruses having at least one genome segment of an equine influenza virus generated by cold-adaptation.</p> |
申请公布号 |
WO0174386(A3) |
申请公布日期 |
2002.05.23 |
申请号 |
WO2001US08968 |
申请日期 |
2001.03.21 |
申请人 |
THE UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION;DOWLING, PATRICIA, W.;YOUNGNER, JULIUS, S. |
发明人 |
DOWLING, PATRICIA, W.;YOUNGNER, JULIUS, S. |
分类号 |
A01K13/00;A61K39/145;A61P11/00;A61P31/04;A61P31/12;A61P31/16;C12N7/08;(IPC1-7):A61K39/145 |
主分类号 |
A01K13/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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