| 摘要 |
<p>The invention relates to a pharmaceutical composition comprising at least one phenol derivative represented by formula (I), wherein R1 represents a hydrogen atom, a halogen atom or a hydrocarbon group containing up to 12 carbon atoms; R2 represents a hydrogen atom or a C¿1?-C7 alkyl group; wherein R?1 and R2¿ may optionally form a carbocyclic 5- or 6-membered ring; R3 represents a hydrogen atom, a halogen atom or a C¿1?-C7 alkyl group; R?4¿ represents a hydrogen atom, a C¿1?-C7 alkyl group or a halogen atom; R?5¿ represents hydrogen atom, a halogen atom or a C¿1?-C7 alkyl group; and R?6¿ represents a hydrogen atom, a C¿1?-C7 alkyl group or a C2 or C3 alkenyl group, under the proviso that R?2 and R4¿ can only both represent a hydrogen atom if both R?1 and R5¿ represent a C¿1?-C7 alkyl group and R?3¿ represents a halogen atom. The composition is particularly useful for the blockade of sodium channels and/or influencing the kinetics of sodium channels and thus can be used as local anesthetic, antidysrhythmic, anticonvulsant/antiepileptic and spasmolytic.</p> |
