发明名称 |
PRODUCTION METHOD OF CITALOPRAM, INTERMMEDIATE THEREFOR AND PRODUCTION METHOD OF THE INTERMEDIATE |
摘要 |
Citalopram can be industrially and economically produced and at a high yield by reacting a compound of the following formula [VI] with 3-(dimethylamino)propyl chloride in the presence of at least one of N,N,N',N'-tetramethylethylenediamine and 1,3-dimethyl-2-imidazolidinone and a condensing agent. The compound of the following formula [III], which is a key compound for the production of citalopram, can be easily produced by subjecting the compound of the following formula [II] to reduction and cyclization.
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申请公布号 |
US2002062040(A1) |
申请公布日期 |
2002.05.23 |
申请号 |
US20010996134 |
申请日期 |
2001.11.28 |
申请人 |
SUMIKA FINE CHEMICALS CO., LTD. |
发明人 |
IKEMOTO TETSUYA;GAO WEI-GUO;ARAI NOBUHIRO;IGI MASAMI |
分类号 |
C07C29/40;C07C33/46;C07C51/265;C07C51/373;C07C65/34;C07D307/87;(IPC1-7):C07C65/32;C07C33/28 |
主分类号 |
C07C29/40 |
代理机构 |
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