| 摘要 |
<p>The immune response to an antigen is enhanced through increasing the concentration of dendritic cells at a targeted site, which site may be the site of antigen contact, or may be the site of antigen presentation to T cells. Dendritic cells are attracted to the targeted site by a localization factor, which factor may be chemokine, cytokine, somatostatin receptor agonists, and the like. The methods may further be practised in conjunction with the expansion of functional dendritic cells in vivo, for example through administration of Flt3-L, GM-CSF, and the like. Also included is the use of maturation factors following antigen acquisition by the dendritic cells.</p> |
