发明名称 |
NOVEL USE OF COMBINED 5-HT1A AGONISTS AND SELECTIVE SEROTONIN REUPTAKE INHIBITORS |
摘要 |
The present invention relates to the use of compounds being combined selective serotonin (5-HT) reuptake inhibitors (SSRIs) and 5-HT1A receptor agonists, in particular of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine or a physiologically acceptable salt thereof or 3-{4-[4-(4-cyano-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carbonitrile or a physiologically acceptable salt thereof, for the manufacture of a medicament for the treatment of chronic pain disorders or in treating other conditions where there is hyper-sensitization to painful signals, hyperalgesia, allodynia, enhanced pain perception, and enhanced memory of pain, as well as for the treatment of irritable bowel syndrome (IBS).
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申请公布号 |
WO0239989(A1) |
申请公布日期 |
2002.05.23 |
申请号 |
WO2001EP12686 |
申请日期 |
2001.11.02 |
申请人 |
MERCK PATENT GMBH;BARTOSZYK, GERD;SEDMAN, EWEN |
发明人 |
BARTOSZYK, GERD;SEDMAN, EWEN |
分类号 |
A61K45/00;A61K31/00;A61K31/4045;A61K31/496;A61P1/00;A61P25/00;A61P25/04;A61P25/06;A61P29/00;A61P43/00;(IPC1-7):A61K31/00 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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