FILLER COMPOSITION FOR SOFT TISSUE AUGMENTATION AND RECONSTRUCTIVE SURGERY

摘要

The present invention relates to a filler composition for soft-tissue augmentation and reconstructive surgery comprising an effective amount of an injectable thermo-gelling solution comprising 0.1 to 5.0 % by weight of chitosan or collagen or a derivative thereof; and 1.0 to 20 % by weight of a salt of polyol or sugar selected from the group consisting of mono-phosphate dibasic salt, mono-sulfate salt and a mono-carboxylic acid salt of polyol or sugar. The solution is stable and turns into a gel within a tem-perature ran ge from 20 to 70 ~C. The gel has a cosmetically acceptable consistency for providing a mechanical support to surrounding soft tissues once injected therein. The composition can thus be used as filler for soft tissue augmentation and reconstructive surgery.