发明名称 |
PROBES FOR CHONDROGENESIS |
摘要 |
Markers for detecting and staging chondrogenesis in cells are provided. In one aspect the markers are isolated polynucleotides, referred to hereinafter as CZF-1 and CZF-2, and fragments thereof. In one embodiment, the CZF-1 polynucleotide comprises the open reading frame sequence set forth in SEQ ID NO.1. In one embodiment, the CZF-2 polynucleotide comprises the open reading frame sequence set forth in SEQ ID NO.3. In another aspect the markers are antibodies, which are immunospecific for proteins encoded by CZF-1 or CZF-2. Methods which employ the present markers to identify cells that have begun to differentiate into chondrocytes are provided. The present invention also relates to the CZ-1 protein and the CZ-2 protein and to polynucleotides or oligonucleotides whose sequences are complementary to the coding sequences of CZF-1 or CZF-2, or regions thereof. |
申请公布号 |
WO0195860(A3) |
申请公布日期 |
2002.05.23 |
申请号 |
WO2001US19108 |
申请日期 |
2001.06.14 |
申请人 |
CASE WESTERN RESERVE UNIVERSITY;HERING, THOMAS, M.;JOHNSTONE, BRIAN |
发明人 |
HERING, THOMAS, M.;JOHNSTONE, BRIAN |
分类号 |
C07K14/47;C12N15/12;C12Q1/68;G01N33/68 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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