| 摘要 |
PROBLEM TO BE SOLVED: To provide a process for combinatorial preparation of a substance library, having both advantages of conventional solid synthesis and liquid synthesis, but capable of substantially avoiding the disadvantages thereof. SOLUTION: This process for the combinatorial preparation of the substance library from n different compounds in an array of n different reaction solutions at n spatially separate reaction sites, is characterized in that at each of the n reaction sites (a) from in each case m reactants, in one reaction or reaction sequence, a zwitterionic compound is obtained dissolved in a polar solvent, (b) the zwitterionic compound is precipitated as a solid by addition of a nonpolar solvent, isolated and then obtained in pure form, (c) if appropriate the zwitterionic compound is further reacted, with each of the n reaction solutions differing from each of the n-1 other reaction solutions in at least one of the m reactants.
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