发明名称 |
CELL LINEAGES EXPRESSING A BIOLOGICALLY ACTIVE FACTOR IX |
摘要 |
<p>Cell lines have been prepared from transgenic mice comprised of a first exogenous DNA sequence encoding human factor IX which is controlled by a promoter region specific for hepatic cells and a second exogenous DNA sequence encoding an oncogene, such as the SV40 virus gene encoding the T-antigen or the mouse c-myc gene, which is controlled by a promoter region specific for hepatic cells. Promoter regions specific for hepatic cells included the promoter region for the factor IX gene and the promoter region for the alpha -1 antitrypsin gene. The cultured cells produce biologically active human factor IX which is then isolated from the culture media.</p> |
申请公布号 |
EP0437599(B1) |
申请公布日期 |
2002.05.22 |
申请号 |
EP19900913241 |
申请日期 |
1990.08.09 |
申请人 |
TRANSGENE S.A. |
发明人 |
JALLAT, SOPHIE;MEULIEN, PIERRE;PAVIRANI, ANDREA;PERRAUD, FREDERIC |
分类号 |
A01K67/027;A61K38/43;C12N5/10;C12N9/64;C12N15/57;C12N15/85;C12R1/91;(IPC1-7):C12N15/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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