| 发明名称 |
Identifying compounds inhibiting DC-sign facilitation of HIV into cells |
| 摘要 |
The present invention demonstrates that a receptor, named DC-SIGN, is specifically expressed on dendritic cells, and facilitates infection of T lymphocytes with HIV. Assays for identifying compounds that modulate the interaction of DC-SIGN and HIV and/or T cells and macrophage are provided. Compounds so identified are also part of the present invention.
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| 申请公布号 |
US6391567(B1) |
申请公布日期 |
2002.05.21 |
| 申请号 |
US20000517605 |
申请日期 |
2000.03.02 |
| 申请人 |
NEW YORK UNIVERSITY |
发明人 |
LITTMAN DAN R.;KWON DOUGLAS;VAN KOOYK YVETTE;GEIJTENBEEK TEUNIS |
| 分类号 |
A61K38/17;A61K39/00;A61P31/18;C07K14/705;C07K16/10;(IPC1-7):G01N33/53;C12Q1/02;C12N15/00;C12N5/00;C12N5/02 |
主分类号 |
A61K38/17 |
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