发明名称 |
Method for inhibiting thrombosis in a patient whose blood is subjected to extracorporeal circulation |
摘要 |
This invention provides a method for inhibiting thrombosis in a patient whose blood is subjected to extracorporeal blood circulation which comprises contacting the extracorporeal circulating blood with a Factor IXa compound in an amount effective to inhibit thrombosis in the blood of a patient and under conditions such that the Factor IXa compound circulates in the patient. The Factor IXa compound may include an active site-blocked Factor IXa compound or Glu-Gly-Arg chloromethyl ketone-inactivated human factor IXa compound. This invention also provides that the effective amount may be from about 0.1 mug/ml plasma to about 250 mug/ml plasma or from about 0.5 mug/ml plasma to about 25 mug/ml plasma. The patient may be subjected to extracorporeal blood circulation during transplant surgery or cardiopulmonary bypass surgery. This invention further provides for a method for inhibiting thrombosis in a patient whose blood is subjected to extracorporeal blood circulation, which comprises contacting the extracorporeal circulating blood with an agent capable of inhibiting a step of the intrinsic pathway of coagulation in an amount effective to inhibit thrombosis in the blood of a patient and under conditions such that the Factor IXa compound circulates in the patient. The agent may be an active site-blocked Factor XII compound or an active site-blocked Factor XI compound.
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申请公布号 |
US6391300(B1) |
申请公布日期 |
2002.05.21 |
申请号 |
US19980192905 |
申请日期 |
1998.11.16 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
ROSE ERIC;STERN DAVID;SCHMIDT ANN MARIE;SPANIER TALIA |
分类号 |
A61K38/36;A61K38/48;A61M1/36;G01N33/86;(IPC1-7):A61K38/36;A61K39/395;C07K14/745;C07K16/36 |
主分类号 |
A61K38/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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