发明名称 |
Stabilized inteferon compositions |
摘要 |
Stabilized pharmaceutical formulations comprising IFN-beta and highly purified mannitol are provided. The highly purified mannitol stabilizes the compositions by reducing the formation of IFN-beta adducts in comparison with IFN-beta formulated with mannitol that has not been highly purified. Methods for increasing the stability of IFN-beta or a variant thereof in a liquid or lyophilized composition and for increasing storage stability of such a composition are also provided. |
申请公布号 |
AU3070702(A) |
申请公布日期 |
2002.05.21 |
申请号 |
AU20020030707 |
申请日期 |
2001.11.07 |
申请人 |
CHIRON CORPORATION |
发明人 |
SIDNEY N. WOLFE;MANINDER S. HORA |
分类号 |
A61M5/28;A61K9/00;A61K9/08;A61K9/19;A61K38/00;A61K38/21;A61K47/02;A61K47/26;A61K47/42 |
主分类号 |
A61M5/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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