发明名称 Antisense oligonucleotide modulation of raf gene expression
摘要 Oligonucleotides are provided which are targeted to nucleic acids encoding human raf and capable of inhibiting raf expression. Methods of inhibiting the expression of human raf using oligonucleotides of the invention are also provided. The present invention further comprises methods of preventing or inhibiting hyperproliferation of cells and methods of treating abnormal proliferative conditions which employ oligonucleotides of the invention.
申请公布号 US6391636(B1) 申请公布日期 2002.05.21
申请号 US20000462261 申请日期 2000.03.01
申请人 ISIS PHARMACEUTICALS, INC. 发明人 MONIA BRETT P.
分类号 A61K38/00;C12N15/113;(IPC1-7):A61K31/708;A61K31/712;C07H21/00;C12N5/08 主分类号 A61K38/00
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