| 发明名称 |
AFC1 and RCE1: isoprenylated CAAX processing enzymes |
| 摘要 |
Two genes which encode polypeptides that mediate post-prenylation processing steps in CAAX polypeptides such as Ras are provided. The two genes (AFC1 and RCE1) encode polypeptides that mediate the removal of the AAX tripeptide from the CAAX polypeptide following prenylation. The genes and encoded polypeptides provide assays for testing compounds for an effect on post-prenylation processing steps. A heat shock assay for assessing Ras activity is also provided.
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| 申请公布号 |
US6391574(B1) |
申请公布日期 |
2002.05.21 |
| 申请号 |
US19980184964 |
申请日期 |
1998.11.03 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
RINE JASPER D.;BOYARTCHUK VICTOR L.;ASHBY MATTHEW N. |
| 分类号 |
G01N33/53;A61K48/00;A61P35/00;C07K16/40;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/60;C12N15/09;C12N15/57;C12Q1/02;C12Q1/37;G01N33/542;G01N33/574;(IPC1-7):C12Q1/37;C12N9/50;C12N1/20;C12N15/52;C12N5/00 |
主分类号 |
G01N33/53 |
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