MONOCLONAL ANTIBODY AGAINST COMPLEXED AND NONCOMPLEXED COMPLEXING AGENTS FOR REMOVING HEAVY METALS FROM AQUEOUS SOLUTIONS AND FOR ANALYSIS

摘要

The invention relates to monoclonal antibodies (mAB) which bind to water-soluble complexones such as ethy- lenediamine tetraacetate (EDTA) or diethylenetriamine pentaacetate (DTPA) with high specificity and avidity and retain their high avidity and specificity for these complexones after complexing of EDTA or DTPA with metal ions. These mAB can therefore be used, e.g. coupled on filters or other supports, for removing toxic heavy metals which are complexed with EDTA or DTPA. Further- more, these mAB are suitable as components of immuno- assays (RIA, ELISA etc.) for the quantitative determina- tion of EDTA or DTPA in aqueous solutions.