发明名称 |
PARTICLE FORMATION METHODS AND THEIR PRODUCTS |
摘要 |
Preparation of particles of an active substance having a layer ofan additive at the particle surfaces, by dissolving both the active substance and the additive in a vehicle to form a target solution, and contacting the target solution with an anti-solvent fluid using a SEDS<TM> particle formation process, to cause the active substance and additive to coprecipitate. The additive is typically a protective additive, in particular a taste and/or odour masking agent. Also provided is a particulate coformulation made by the method, which has a finite gradient in the relative additive concentration, which concentration increases radially outwards from the active rich core to the additive-rich surface of the particles. |
申请公布号 |
WO0238127(A2) |
申请公布日期 |
2002.05.16 |
申请号 |
WO2001GB04873 |
申请日期 |
2001.11.01 |
申请人 |
BRADFORD PARTICLE DESIGN LTD.;HANNA, MAZEN, HERMIZ;YORK, PETER |
发明人 |
HANNA, MAZEN, HERMIZ;YORK, PETER |
分类号 |
A23L1/00;A23L1/015;A61J3/02;A61K9/16;A61K9/50;A61K9/52;A61K31/49;A61K47/30;A61P33/06;B01J3/00;B01J19/00 |
主分类号 |
A23L1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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