| 摘要 |
<p>A natural type α-amino acid which is easily available and inexpensive is converted to a compound represented by the formula (1), which is reacted with an organometallic reagent represented by the formula (2) to obtain an optically active 5-hydroxyoxazolidine derivative represented by the formula (3). The derivative (3) is treated with an acid to obtain an optically active amino ketone derivative represented by the formula (4), which is subjected to reduction, etc. to obtain an optically active amino alcohol derivative represented by the formula (5) or (6). General formula (2) General formula (1) General formula (3) General formula (4) General formula (5) or General formula (6) Thus, the optically active amino alcohol derivative represented by the formula (5) or (6) having a satisfactory optical purity, which is useful as an intermediate for medicines, agricultural chemicals, etc., can be stereoselectively produced stably at low cost from a natural type α-amino acid as an easily available, inexpensive starting material without causing racemization. Also provided are: the optically active 5-hydroxyoxazolidine derivative represented by the formula (3) and the amino ketone derivative represented by the formula (4), which are important intermediates for this production; and processes for producing these.</p> |
