发明名称 |
Inhibition of major groove DNA binding proteins by modified polyamides |
摘要 |
<p>This invention provides improved polyamides comprising a positive patch for contacting the phosphate backbone or major groove of a DNA molecule. As such, the improved polyamides are capable of inhibiting the function or binding of a DNA-binding protein to a DNA molecule. The improved polyamide provides for more efficient function of the polyamide.</p> |
申请公布号 |
AU747668(B2) |
申请公布日期 |
2002.05.16 |
申请号 |
AU19980061588 |
申请日期 |
1998.02.13 |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY |
发明人 |
ELDON E. BAIRD;PETER B. DERVAN |
分类号 |
A61K38/00;A61K31/40;A61K31/415;A61K31/4178;A61K31/785;A61K38/04;A61K41/00;A61K47/48;A61K49/00;A61P43/00;C07D207/34;C07D233/90;C07D403/12;C07D403/14;C07H21/04;C07K5/078;C07K7/02;C07K7/04;C08G69/00;C08G69/08;C12N15/09;C12Q1/68;(IPC1-7):C07K7/02 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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